Objective To explore the effect of the design and application of auditory hallucination self-management records for patients with schizophrenia. Methods The auditory hallucination self-management records for schizophrenia patients is composed of three parts: table head, items and remarks. A convenient sampling method was adopted to select two male wards and two female ones from adult psychiatric department in a tertiary psychiatric hospital in Jiangsu Province. The two wards in the experimental group and the control group were taken randomly by flipping a coin based on the gender differences. 20 cases admitted in hospital from January 2017 to December 2018 from each ward were conveniently selected. A total of 80 cases of hospitalized patients with schizophrenia and their main caregivers were selected. The control group received conventional drug therapy,nursing and management of auditory hallucination. On the basis of the intervention in the control group,patients in the experimental group were given the extra of auditory hallucination self-management record sheets to guide patients for self-management. The results and effects of two groups were compared before intervention,at one month,three months,and six months after the intervention. Results 34 patients in the experimental group and 30 patients in the control group completed the study. There were no significant differences in the scales of Positive and Negative Syndrome(PANSS)(anxiety,tension,preemption),impulsive behavior risk assessment scale and medication adherence rating scale between the two groups before intervention(P>0.05). The scales of PANSS(anxiety,tension,preemption),impulsive behavior risk assessment scale and medication adherence scores of the two groups were statistically significant after intervention(P<0.05). With the extension of the intervention time,the scales of PANSS(anxiety,tension,preemption)and impulsive behavior risk assessment scales of the experimental group were significantly lower than those in the control group,and the medication adherence rating scale was significantly higher than those in the control group. These differences were statistically significant(P<0.05). Conclusion Management of patients with schizophrenia by auditory hallucination self-management record sheet can effectively identify,cope with and manage auditory hallucinations and alleviate the impact of auditory hallucinations on their mood and behavior.